HCID 23675480, compound → HCID 68109497, compound

Participants

Reaction Steps

The product of Example 29, step B and sodium 3,5-dichlorobenzenesulfinate were coupled using the procedure of Example 29, step C. Purification by flash column chromatography (SiO2, 85:15 hexane/ethyl acetate) provided tert-butyl 8-(3,5-dichlorophenylsulfonyl)-3,4-dihydrobenzofuro[3,2-c]pyridine-2(1H)-carboxylate (147 mg, 43%) as a yellow oil: 1H NMR (CDCl3, 300 MHz) δ 8.07 (s, 1H), 7.85-7.78 (m, 3H), 7.56 (d, J=8.7 Hz, 1H), 7.50 (t, J=1.8 Hz, 1H), 4.59 (s, 2H), 3.84 (t, J=5.4 Hz, 2H), 2.93-2.82 (m, 2H), 1.51 (s, 9H).

Provenance & Evidence