Hydrochloric Acid → HCID 68109152, compound

Participants

Reaction Steps

The product of step B was converted to the hydrochloride salt by dissolving in methanol and treating with 1.25 M HCl in methanol. The reaction mixture was concentrated in vacuo to give 8-(1-naphthylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine hydrochloride (52 mg, 100%, AUC HPLC 94.5%) as a white solid: mp 200-202° C.; 1H NMR (DMSO-d6, 300 MHz) δ 9.51 (br s, 2H), 8.61-8.45 (m, 3H), 8.33 (d, J=8.1 Hz, 1H), 8.14-8.05 (m, 1H), 7.87 (dd, J=8.7, 2.1 Hz, 1H), 7.82-7.74 (m, 2H), 7.69-7.57 (m, 2H), 4.39 (s, 2H), 3.58-3.45 (m, 2H), 3.10 (t, J=5.7 Hz, 2H); ESI MS m/z 364 [M+H]+.

Provenance & Evidence