HCID 23675619, compound → HCID 68109050, compound

Participants

Reaction Steps

The product of Example 29, step B and sodium 2-naphthylsulfinate were coupled using the procedure of Example 29, step C. Purification by flash column chromatography (SiO2, 80:20 hexane/ethyl acetate) provided tert-butyl 8-(2-naphthylsulfonyl)-3,4-dihydrobenzofuro[3,2-c]pyridine-2(1H)-carboxylate (450 mg, 85%) as an orange solid: 1H NMR (CDCl3, 300 MHz) δ 8.58 (s, 1H), 8.14 (s, 1H), 8.02-7.82 (m, 5H), 7.66-7.56 (m, 2H), 7.50 (d, J=8.7 Hz, 1H), 4.57 (s, 2H), 3.82 (t, J=5.4 Hz, 2H), 2.90-2.80 (m, 2H), 1.50 (s, 9H).

Provenance & Evidence