Hydrochloric Acid → HCID 68109183, compound

Participants

Reaction Steps

The product of step B (50 mg, 0.10 mmol) was converted to hydrochloride salt by dissolving in chloroform and treating with 1.25 M HCl in methanol. The reaction mixture was concentrated in vacuo to give 8-(2-naphthylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine hydrochloride (52 mg, 95%, AUC HPLC>99%) as a white solid: mp 267-270° C.; 1H NMR (DMSO-d6, 300 MHz) δ 9.58 (br s, 2H), 8.71 (s, 1H), 8.45 (d, J=1.8 Hz, 1H), 8.24-8.17 (m, 1H), 8.12 (d, J=8.7 Hz, 1H), 8.06-7.88 (m, 3H), 7.82 (d, J=8.7 Hz, 1H), 7.77-7.65 (m, 2H), 4.39 (s, 2H), 3.57-3.47 (m, 2H), 3.16-3.06 (m, 2H); ESI MS m/z 364 [M+H]+.

Provenance & Evidence