tert-Butyl 4-oxopiperidine-1-carboxylate → HCID 68109270, compound

Participants

Reaction Steps

The product of step A was reacted with tert-butyl 4-oxopiperidine-1-carboxylate then Boc protected following the procedure of Example 29, step B. Purification by flash column chromatography (SiO2, 9:1 hexanes/ethyl acetate) provided tert-butyl 6-fluoro-8-bromo-3,4-dihydrobenzofuro[3,2-c]pyridine-2(1H)-carboxylate (320 mg, 14%) as an off-white solid: 1H NMR (CDCl3, 400 MHz) δ 7.33 (s, 1H), 7.16 (dd, J=10.0, 1.6 Hz, 1H), 4.51 (br s, 2H), 3.83 (br s, 2H), 2.88 (br s, 2H), 1.51 (s, 9H).

Provenance & Evidence