HCID 68109162, compound → HCID 68108961, compound

Participants

Reaction Steps

The product of step A was coupled with lithium 2-(tert-butoxycarbonyl)-6-chloro-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine-8-sulfinate following the procedure of Example 50, step A. The crude product was purified by flash column chromatography (SiO2, 7:3 hexanes/ethyl acetate) to give tert-butyl 6-chloro-8-((4-(hydroxymethyl)phenyl)sulfonyl)-3,4-dihydrobenzofuro[3,2-c]pyridine-2(1H)-carboxylate (30 mg, 7%) as an off-white solid: 1H NMR (CDCl3, 300 MHz) δ 8.02-7.89 (m, 3H), 7.82 (s, 1H), 7.53 (d, J=8.1 Hz, 2H), 4.77 (d, J=5.4 Hz, 2H), 4.56 (s, 2H), 3.83 (t, J=5.7 Hz, 2H), 2.97-2.85 (m, 2H) 1.50 (s, 9H).

Provenance & Evidence