Hydrochloric Acid → HCID 68109101, compound

Participants

Reaction Steps

The product obtained in step C (13 mg, 0.03 mmol) was converted to hydrochloride salt by dissolving in dichloromethane and treating with 1.25 M HCl in methanol. The reaction mixture was concentrated in vacuo to give 8-((3-fluorophenyl)sulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine-6-carbonitrile hydrochloride (13.5 mg, 95%, AUC HPLC>99%) as a white solid: mp <<MP data>>; 1H NMR (DMSO-d6, 400 MHz) δ 9.25 (br s, 2H), 8.76 (d, J=2.0 Hz, 1H), 8.59 (d, J=2.0 Hz, 1H), 7.97-7.86 (m, 2H), 7.75-7.66 (m, 1H), 7.64-7.55 (m, 1H), 4.39 (s, 2H), 3.53 (t, J=6.0 Hz, 2H), 3.22-3.12 (m, 2H); APCI MS m/z 357 [M+H]+.

Provenance & Evidence