Hydrochloric Acid → HCID 68109300, compound

Participants

Reaction Steps

The product obtained in step C (23 mg, 0.06 mmol) was converted to the hydrochloride salt by dissolving in dichloromethane and treating with 1.25 M HCl in methanol. The reaction mixture was concentrated in vacuo to give 8-(phenylsulfonyl)-6-(1H-pyrazol-1-yl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine hydrochloride (24 mg, 96%, AUC HPLC 98.6%) as a white solid: mp <<MP data>>; 1H NMR (DMSO-d6, 400 MHz) δ 9.35 (br s, 2H), 8.69-8.65 (m, 1H), 8.36 (d, J=2.0 Hz, 1H), 8.30 (d, J=1.6 Hz, 1H), 8.05-7.99 (m, 2H), 7.92 (d, J=1.6 Hz, 1H), 7.74-7.59 (m, 3H), 6.89 (d, J=2.0 Hz, 1H), 4.43 (s, 2H), 3.55 (t, J=6.0 Hz, 2H), 3.17 (t, J=6.0 Hz, 2H); ESI MS m/z 380 [M+H]+.

Provenance & Evidence