Hydrochloric Acid → HCID 68108635, compound

Participants

Reaction Steps

6-chloro-3-methyl-8-(phenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine (100 mg, 0.3 mmol) was converted to the hydrochloride salt by dissolving in methanol and treating with 1.25 M HCl in methanol. The reaction mixture was concentrated in vacuo to give 6-chloro-3-methyl-8-(phenylsulfonyl)-1,2,3,4-tetra hydrobenzofuro[3,2-c]pyridine hydrochloride (81b, 108 mg, 96%, AUC HPLC 98.1%): mp <<MP data>>; 1H NMR (DMSO-d6, 400 MHz) δ 9.62 (br, 2H), 8.41 (d, J=1.6 Hz, 1H), 8.04-8.02 (m, 3H), 7.71-7.62 (m, 3H), 4.51-4.32 (m, 2H), 3.77-3.72 (m, 1H), 3.26-3.24 (m, 1H), 2.98-2.91 (m, 1H), 1.44 (d, J=6.4 Hz, 3H); ESI MS m/z 403 [M+H+CH3CN]+.

Provenance & Evidence