Hydrochloric Acid → HCID 68109219, compound

Participants

Reaction Steps

To a stirred solution of the product of Example 85, step C (80 mg, 0.12 mmol) in water (5 mL) and tetrahydrofuran (5 mL) was added lithium hydroxide monohydrate (84 mg, 2.0 mmol) at ambient temperature. After 2 h, 1 M HCl solution (3 mL) was added. The mixture was extracted with dichloromethane (2×10 mL) and the combined organic extracts were dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated in vacuo to give 2-(tert-butoxycarbonyl)-6-chloro-8-(phenylsulfonyl)-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine-1-carboxylic acid (80 mg, 99%) as a colorless oil which was used directly in the next step.

Provenance & Evidence