Hydrochloric Acid → HCID 68109424, compound

Participants

Reaction Steps

The product obtained from step E (5 mg, 0.01 mmol) was converted to the hydrochloride salt by dissolving in dichloromethane and treating with 1.25 M HCl in methanol. The reaction mixture was concentrated in vacuo to give 6-methoxy-8-phenoxy-1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine hydrochloride (5.5 mg, 97%, AUC HPLC 95.9%) as a white solid: mp <<MP data>>; 1H NMR (DMSO-d6, 400 MHz) δ 8.97 (br s, 2H), 7.41-7.33 (m, 2H), 7.13-7.07 (m, 1H), 7.00-6.94 (m, 2H), 6.82 (d, J=2.4 Hz, 1H), 6.76 (d, J=2.0 Hz, 1H), 4.20 (s, 2H), 3.90 (s, 3H), 3.54-3.45 (m, 2H), 3.09-3.00 (m, 2H); APCI MS m/z 296 [M+H]+.

Provenance & Evidence