HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Thioglycolate → 6-Bromo-benzo[b]thiophene-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Thioglycolate | HCID 16907 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Bromo-2-fluorobenzaldehyde | HCID 143517 | — |
| Product | 6-Bromo-benzo[b]thiophene-2-carboxylic acid methyl ester | HCID 22474078 | — |
Reaction Steps
Starting from 6.54 g (32.2 mmol) of 4-bromo-2-fluorobenzaldehyde, by general method A with 1.93 g (48.3 mmol) of sodium hydride (60% in liquid paraffin) and 3.76 g (35.5 mmol) of methyl mercaptoacetate, 4.06 g (46% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09067931B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-52176ede974d45248f501105e0b01f3e |
| Source note | uspto-grants-2015_06 |