HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Thioglycolate → methyl 5-bromo-1-benzothiophene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Thioglycolate | HCID 16907 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 5-Bromo-2-fluorobenzaldehyde | HCID 736327 | — |
| Product | methyl 5-bromo-1-benzothiophene-2-carboxylate | HCID 2824065 | — |
Reaction Steps
Starting from 2.99 g (14.7 mmol) of 5-bromo-2-fluorobenzaldehyde, by general method A with 0.88 g (22.1 mmol) of sodium hydride (60%) and 1.72 g (16.2 mmol) of methyl mercaptoacetate, 2.76 g (69.1% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09067931B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-7ea8d02e30a0474a9681163e1ce527b3 |
| Source note | uspto-grants-2015_06 |