Thionyl Chloride → 2-(1-(2-Methoxyethyl)piperidin-4-ylidene)acetyl chloride hydrochloride

HRID 217966Notes

Reaction equation

HRID 217966 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][C:8](=[CH:11][C:12]([OH:14])=O)[CH2:7][CH2:6]1.S(Cl)([Cl:17])=O>>[ClH:17].[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][C:8](=[CH:11][C:12]([Cl:17])=[O:14])[CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 593826602-(1-(2-Methoxyethyl)piperidin-4-ylidene)acetic acid

Product 1

HCID 866297582-(1-(2-Methoxyethyl)piperidin-4-ylidene)acetyl chloride hydrochloride

Procedure

2.4 g of 2-(1-(2-methoxyethyl)piperidin-4-ylidene)acetic acid was dissolved in 20 mL of thionyl chloride, refluxed for 2 hours, evaporated in vacuo to remove thionyl chloride and give a solid product.

Workup

  1. temperaturerefluxed for 2 hours
  2. customevaporated in vacuo
  3. customto remove thionyl chloride
  4. customgive a solid product

Sources & evidence

ORD record
ord-6b659d0ea5c0469bb063364fae0ab922
Source dataset
uspto-grants-2012_06
Patent number
US08198301B2

Reaction notes

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