Acetic Acid → HCID 67314169, compound

HRID 2179715Notes

Reaction equation

HRID 2179715 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C@@H:3]([NH:9][C:10]([C:12]1[O:13][C:14]3[C:20]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[O:27][CH3:28])=[CH:19][CH:18]=[CH:17][C:15]=3[CH:16]=1)=[O:11])[CH2:2]2.[C:29]([OH:32])(=[O:31])[CH3:30]>CO>[C:29]([OH:32])(=[O:31])[CH3:30].[N:1]12[CH2:6][CH2:5][CH:4]([CH2:7][CH2:8]1)[C@@H:3]([NH:9][C:10]([C:12]1[O:13][C:14]3[C:20]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=4[O:27][CH3:28])=[CH:19][CH:18]=[CH:17][C:15]=3[CH:16]=1)=[O:11])[CH2:2]2

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 9976826HCID 9976826, compound

Product 1

HCID 67314169HCID 67314169, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

95.9 mg (0.25 mmol) of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(2-methoxyphenyl)-1-benzofuran-2-carboxamide (Example 130) are dissolved in 2 ml of methanol. After addition of 15.3 mg (0.25 mmol) of acetic acid, the mixture is concentrated and the residue is dried under high vacuum. 114.9 mg (99.7% of theory) of the title compound are obtained.

Workup

  1. concentrationthe mixture is concentrated
  2. customthe residue is dried under high vacuum

Sources & evidence

ORD record
ord-3a081a76f7f641c8a27dee252735e26a
Source dataset
uspto-grants-2015_06
Patent number
US09067931B2

Reaction notes

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