反应详情

To a stirred solution of tert-butyl (1S,4R)-4-(hydroxymethyl)cyclopent-2-enylcarbamate (step 1, about 10.0 g) in ethanol (150 ml) 10% palladium on carbon (about 1.0 g) was added and kept under hydrogen atmosphere. Reaction mass was stirred for about 16 hours. Completion of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was filtered through high-flow bed and washed with ethanol. The filtrate was concentrated under reduced pressure to furnish the title compound (7.5 g) as a light yellow liquid. ES Mass: 215 [M+1] 216 (100%).

1. customReaction mass
2. customAfter completion of the reaction
3. filtrationthe reaction mixture was filtered through high-flow bed
4. washwashed with ethanol
5. concentrationThe filtrate was concentrated under reduced pressure