HCID 66858871, compound → HCID 66858638, compound

Participants

Reaction Steps

To a solution of ethyl 1-((1R,3S)-3-(benzyloxycarbonylamino)-2,2-dimethylcyclobutanecarbonyl)piperidine-4-carboxylate (step 1, 1.30 g) in ethyl acetate (50 ml), Pd/C (100 mg) was added carefully under argon atmosphere. Then the reaction mixture was stirred for overnight under hydrogen conditions. After completion of the reaction (monitored by TLC), diluted with ethyl acetate, filtered on celite, washed with ethyl acetate. The combined organic extracts were concentrated under reduced pressure to give crude product which was preceded for next step without further purification and analysis.

Provenance & Evidence