N-methyl-2-pyrrolidone → HCID 68184795, compound

Participants

Reaction Conditions

Reaction Steps

Under the nitrogen atmosphere, 7-methoxy-2,2′-binaphthalen (31.0) as the sixth intermediate compound, pyridine hydrochloride (63.0 g) and N-methylpyrrolidone (20 ml) were added to a flask and then stirred for 7 hours at 200° C. Once the heating is completed, it was cooled to 100° C. or less and added with water. The solid precipitated by adding water was collected by suction filtration. The obtained solid was purified by silica gel column chromatography (solvent: toluene) to give [2,2′-binaphthalen]-7-ol (22.0 g) as a seventh intermediate compound. The scheme is shown in the following “Reaction 12”.

Provenance & Evidence