N-methyl-2-pyrrolidone → HCID 86701360, compound

Participants

Reaction Conditions

Reaction Steps

Under the nitrogen atmosphere, 9-(4-ethoxynaphthalen-1-yl)anthracene (87.1 g) as the fourteenth intermediate compound, pyridine hydrochloride (289.0 g) and 1-methyl-2-pyrrolidone (87 ml) were added to a flask, and stirred for 16 hours at 175° C. The reaction solution was cooled to room temperature, added with water, and washed while being heated. After suction filtration, the solid remained after dissolution was collected. The obtained solid was washed with methanol while being heated. It was then dissolved in heated chlorobenzene and subjected to suction filtration by using a Kiriyama funnel layered with silica gel. An appropriate amount of filtrate was distilled off under reduced pressure, and by adding heptane, re-precipitation was performed to give 4-(anthracen-9-yl)naphthalen-1-ol (74.3 g) as a fifteenth intermediate compound. The scheme is shown in the following “Reaction 26”.

Provenance & Evidence