Diisopropylamine → HCID 91139094, compound

HRID 2179907Notes

Reaction equation

HRID 2179907 reaction equation
[CH:1]([NH:4][CH:5]([CH3:7])[CH3:6])([CH3:3])[CH3:2].[CH3:8][C@@:9]12[O:19][C@H:18]1[C@@H:17]1[O:20][C@@H:16]1[C:15]1[C:21]([O:23][C@H:13]([CH:14]=1)[C@@H:12]1[C:24]([C:26]([O:28][C@H:11]1[CH2:10]2)=[O:27])=[CH2:25])=[O:22]>CC(C)=O>[CH:1]([N:4]([CH2:25][CH:24]1[CH:12]2[CH:11]([CH2:10][C:9]3([CH3:8])[CH:18]([CH:17]4[CH:16]([C:15]5[C:21](=[O:22])[O:23][CH:13]2[CH:14]=5)[O:20]4)[O:19]3)[O:28][C:26]1=[O:27])[CH:5]([CH3:7])[CH3:6])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 7912DiisopropylamineHCID 442282HCID 442282, compound

Product 1

HCID 91139094HCID 91139094, compoundYield 25.5%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Diisopropylamine (500 μmol; 70 μl) is added to a solution of mikanolide (100 μmol; 29 mg) in acetone (1 ml). The reaction mass is stirred for 30 minutes at ambient temperature then the solvent is eliminated by evaporation under reduced pressure. The residue is taken up in ether, filtered and dried under vacuum. 10 mg of product is obtained in the form of a white powder.

Workup

  1. customthe solvent is eliminated by evaporation under reduced pressure
  2. filtrationfiltered
  3. customdried under vacuum

Sources & evidence

ORD record
ord-f8c00701ed064db694c0e69151198392
Source dataset
uspto-grants-2005_05
Patent number
US06887869B2

Reaction notes

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