Dimethylamine → HCID 86592994, compound

HRID 2179908Notes

Reaction equation

HRID 2179908 reaction equation
[CH3:1][NH:2][CH3:3].[CH3:4][C@H:5]1[C:23](=[O:24])[O:22][C@H:7]2[CH2:8][C@:9]3([CH3:21])[O:11][C@H:10]3[C@@H:12]3[O:14][C@@H:13]3[C:15]3[C:19](=[O:20])[O:18][C@@H:17]([C@H:6]12)[CH:16]=3>CC(C)=O>[CH3:1][N:2]([CH3:3])[CH:13]1[C:15]2=[CH:16][CH:17]([O:18][C:19]2=[O:20])[CH:6]2[CH:7]([O:22][C:23](=[O:24])[CH:5]2[CH3:4])[CH2:8][C:9]2([CH3:21])[CH:10]([O:11]2)[CH:12]1[OH:14]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 442200Dihydromikanolide

Product 1

HCID 86592994HCID 86592994, compoundYield 74.1%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A solution of dimethylamine (500 μmol, 250 μl, 2M in THF) is added to a solution of dihydromikanolide (100 μmol, 29 mg) in acetone (1 ml). The reaction mass is stirred for 2 hours at ambient temperature then the solvent is eliminated by evaporation under reduced pressure. The residue is taken up in ether, filtered and dried under vacuum. 25 mg of product is obtained in the form of a white powder.

Workup

  1. customthe solvent is eliminated by evaporation under reduced pressure
  2. filtrationfiltered
  3. customdried under vacuum

Sources & evidence

ORD record
ord-819d8448a5ad4bd1b1c0908141bff7e0
Source dataset
uspto-grants-2005_05
Patent number
US06887869B2

Reaction notes

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