Acetone → HCID 131724850, compound

HRID 2179910Notes

Reaction equation

HRID 2179910 reaction equation
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[CH3:9][N:10]([CH3:32])[CH:11]1[C:25]2=[CH:26][CH:22]([O:23][C:24]2=[O:27])[CH:21]2[CH:17]([O:18][C:19](=[O:29])[CH:20]2[CH3:28])[CH2:16][C:15]2([CH3:30])[CH:13]([O:14]2)[CH:12]1[OH:31].CC(C)=O>>[C:1]([O-:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([O-:6])=[O:5].[OH:31][CH:12]1[CH:11]([NH+:10]([CH3:9])[CH3:32])[C:25]2=[CH:26][CH:22]([O:23][C:24]2=[O:27])[CH:21]2[CH:17]([O:18][C:19](=[O:29])[CH:20]2[CH3:28])[CH2:16][C:15]2([CH3:30])[CH:13]1[O:14]2.[OH:31][CH:12]1[CH:11]([NH+:10]([CH3:9])[CH3:32])[C:25]2=[CH:26][CH:22]([O:23][C:24]2=[O:27])[CH:21]2[CH:17]([O:18][C:19](=[O:29])[CH:20]2[CH3:28])[CH2:16][C:15]2([CH3:30])[CH:13]1[O:14]2

Participants

4

Reactant 3

HCID 180Acetone2×HCID 444972Fumaric AcidHCID 86592994HCID 86592994, compound

Product 1

HCID 131724850HCID 131724850, compoundYield 37.9%

Procedure

A solution of fumaric acid (0.1 mmol; 11.6 mg) in acetone (3 ml) is added to a solution of the compound of Example 5 (0.1 mmol; 34 mg) in acetone (0.5 ml). The precipitate is filtered, washed with acetone and dried under reduced pressure. 15 mg of the expected product is obtained in the form of a white powder. Melting point: 159° C.

Workup

  1. filtrationThe precipitate is filtered
  2. washwashed with acetone
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-f4447ee2ff9344e2825994be84b82438
Source dataset
uspto-grants-2005_05
Patent number
US06887869B2

Reaction notes

Loading…