反应详情

Acetic anhydride (150 μmol; 15 μl) is added to a solution of the compound of Example 9 (100 μmol; 40 mg) in pyridine (0.5 ml). The solution obtained is stirred for 20 hours then the reaction mass is poured into water. The aqueous phase is extracted twice with ethyl acetate and the organic phase obtained is washed with water then with a solution of sodium chloride. The organic phase is dried over magnesium sulphate, filtered then evaporated. The residue is eluted on silica with a mixture of isopropyl acetate and dichloromethane (20/80). 16 mg of product is obtained in the form of a white powder.

1. customThe solution obtained
2. extractionThe aqueous phase is extracted twice with ethyl acetate
3. customthe organic phase obtained
4. washis washed with water
5. dry with materialThe organic phase is dried over magnesium sulphate
6. filtrationfiltered
7. customthen evaporated
8. washThe residue is eluted on silica with a mixture of isopropyl acetate and dichloromethane (20/80)