HRID2179914

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7412

Benzoyl chloride

C7H5ClO

结构：CC1CCN(C2C3=CC(OC3=O)C3C(CC4(C)OC4C2O)OC(=O)C3C)CC1

HCID73207834

未命名化合物

结构：CC(=O)OC1C(N2CCC(C)CC2)C2=CC(OC2=O)C2C(CC3(C)OC13)OC(=O)C2C

HCID73207857

未命名化合物

PRODUCTS

生成物

结构：CC1CCN(C2C3=CC(OC3=O)C3C(CC4(C)OC4C2OC(=O)c2ccccc2)OC(=O)C3C)CC1

HCID85332193

未命名化合物

收率 50.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

Benzoyl chloride (400 μmol; 46 μl) is added to a solution of the compound of Example 9 (100 μmol; 40 mg) in pyridine (0.5 ml). The reaction mass is stirred for 2 hours then treated in the same manner as for the preparation of the compound of Example 17. 25 mg of product is obtained in the form of a white powder. Melting point: 234° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-67f26becb8f741b5be0e7d71fb621c5d
来源数据集: uspto-grants-2005_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06887869B2
来源说明: uspto-grants-2005_05

反应 SMILES

[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:10][CH:11]1[CH:25]([N:26]2[CH2:31][CH2:30][CH:29]([CH3:32])[CH2:28][CH2:27]2)[C:24]2=[CH:33][CH:21]([O:22][C:23]2=[O:34])[CH:20]2[CH:16]([O:17][C:18](=[O:36])[CH:19]2[CH3:35])[CH2:15][C:14]2([CH3:37])[CH:12]1[O:13]2.C(OC1C(N2CCC(C)CC2)C2=CC(OC2=O)C2C(OC(=O)C2C)CC2(C)C1O2)(=O)C>N1C=CC=CC=1>[CH3:35][CH:19]1[C:18](=[O:36])[O:17][CH:16]2[CH:20]1[CH:21]1[CH:33]=[C:24]([CH:25]([N:26]3[CH2:31][CH2:30][CH:29]([CH3:32])[CH2:28][CH2:27]3)[CH:11]([O:10][C:1]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[O:8])[CH:12]3[C:14]([CH3:37])([CH2:15]2)[O:13]3)[C:23](=[O:34])[O:22]1