Benzoyl chloride → HCID 85332193, compound

HRID 2179914Notes

Reaction equation

HRID 2179914 reaction equation
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:10][CH:11]1[CH:25]([N:26]2[CH2:31][CH2:30][CH:29]([CH3:32])[CH2:28][CH2:27]2)[C:24]2=[CH:33][CH:21]([O:22][C:23]2=[O:34])[CH:20]2[CH:16]([O:17][C:18](=[O:36])[CH:19]2[CH3:35])[CH2:15][C:14]2([CH3:37])[CH:12]1[O:13]2.C(OC1C(N2CCC(C)CC2)C2=CC(OC2=O)C2C(OC(=O)C2C)CC2(C)C1O2)(=O)C>N1C=CC=CC=1>[CH3:35][CH:19]1[C:18](=[O:36])[O:17][CH:16]2[CH:20]1[CH:21]1[CH:33]=[C:24]([CH:25]([N:26]3[CH2:31][CH2:30][CH:29]([CH3:32])[CH2:28][CH2:27]3)[CH:11]([O:10][C:1]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[O:8])[CH:12]3[C:14]([CH3:37])([CH2:15]2)[O:13]3)[C:23](=[O:34])[O:22]1

Participants

5

Reactant 3

HCID 7412Benzoyl chlorideHCID 73207834HCID 73207834, compoundHCID 73207857HCID 73207857, compound

Product 1

HCID 85332193HCID 85332193, compoundYield 50.4%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Benzoyl chloride (400 μmol; 46 μl) is added to a solution of the compound of Example 9 (100 μmol; 40 mg) in pyridine (0.5 ml). The reaction mass is stirred for 2 hours then treated in the same manner as for the preparation of the compound of Example 17. 25 mg of product is obtained in the form of a white powder. Melting point: 234° C.

Sources & evidence

ORD record
ord-67f26becb8f741b5be0e7d71fb621c5d
Source dataset
uspto-grants-2005_05
Patent number
US06887869B2

Reaction notes

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