2,4-Dichlorobenzoyl chloride → 2-[(3-Bromo-thiophen-2-ylmethyl)-(2,4-dichloro-benzoyl)-amino]-3-phenyl-propionic acid tert-butyl ester

Participants

Reaction Steps

To a stirred solution of 2-[(3-Bromo-thiophen-2-ylmethyl)-amino]-3-phenyl-propionic acid tert-butyl ester (91.6 mg, 0.231 mmol) in dichloromethane (3.3 ml) and N,N-diisopropylethylamine (44 μl) was added a solution of 2,4-Dichloro-benzoyl chloride (34 μl, 0.243 mmol) in dichloromethane (1.3 ml). The reaction mixture was stirred at room temperature under nitrogen overnight. Then, the mixture was extracted with sodium bicarbonate/dichloromethane. The extract was dried (sodium sulfate) and evaporated under reduced pressure to yield 2-[(3-Bromo-thiophen-2-ylmethyl)-(2,4-dichloro-benzoyl)-amino]-3-phenyl-propionic acid tert-butyl ester with 92% yield. 1H NMR(Varian 400 MHz, CDCl3) δ(ppm) presence of rotomers 8.08 (d, 0.5H, J=8.7 Hz, ArH), 7.56 (d, 0.5H, J=2.0 Hz, ArH), 7.40 (m, 2H, ArH), 7.23 (m, 2.5H, ArH), 6.99 (d, 0.5H, J=5.4 Hz, ArH), 6.92 (m, 2H, ArH), 6.83 (d, 0.5H, J=5.0 Hz, ArH), 6.54 (d, 1H, J=7.1 Hz, ArH), 5.78 (d, 0.5H, J=8.0 Hz, ArH), 5.20 (m, 1H, NCH2), 4.85 (m, 1H, NCH2), 4.16 (m, 1H, CHCH2), 3.10 (m, 2H, CHCH2), 1.47 (s, 9H, tBu).

Provenance & Evidence