2-Iodo-1-benzofuran → 2-[(3-Benzofuran-2-yl-prop-2-ynyl)-(2,4-dichloro-benzoyl)-amino]-3-phenyl-propionic acid methyl ester

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Reaction Steps

To a solution of 2-[(2,4-Dichloro-benzoyl)-prop-2-ynyl-amino]-3-phenyl-propionic acid methyl ester (prepared according to example 9) (50 mg, 0.128 mmol) and 2-iodobenzofuran (41 mg, 0.166 mmol) in DMF (2 mL), triethylamine (2 mL) and tetrakis(triphenylphosphine)palladium(0) (15 mg, 0.01 mmol) were added and the reaction mixture was stirred under reflux conditions for 4 h under a N2 atmosphere. DMF and triethylamine were removed under reduced pressure and the residue was partitioned between water and ethyl acetate. The organic layer was separated, dried (Na2SO4), concentrated and the residue was purified by column chromatography using ethyl acetate and hexane (1:4) as eluent to obtain 2-[(3-Benzofuran-2-yl-prop-2-ynyl)-(2,4-dichloro-benzoyl)-amino]-3-phenyl-propionic acid methyl ester as a thick syrup, 50 mg (76%). The compound contains two other rotamers. 1H-NMR (CDCl3, 300 MHz): δ7.58-7.09 (m, 12H), 6.98 (s, minor rotamer), 6.97 (d, minor rotamer), 6.85 (dd, minor rotamer), 6.83 (s, 1H), 5.82 (d, minor rotamer), 5.25 (bs, minor rotamer), 5.10 (bs, minor rotamer), 4.88-4.52 (m, minor rotamer), 4.35-3.21 (m, 5H), 3.78 (s, 3H), 3.76, 3.65 (2s, minor rotamer).

Provenance & Evidence