Hydrochloric Acid → HCID 69803643, compound

Participants

Reaction Steps

[(3R)-3-(5-Chloro-2-cyano-4-fluorophenoxy)-3-phenylpropyl]methyl carbamic acid 1,1-dimethylethyl ester (220 mg, 0.525 mmol) was stirred in a 4N solution of hydrogen chloride in dioxan (20 ml) for 20 minutes. The hydrochloride salt was,applied to a silica gel column and eluted with 10% 7N ammonia in methanol/dichloromethane. The free base was then converted into an oxalate salt with 1 equivalent of oxalic acid in ethanol. The title compound was obtained as a colourless solid (175 mg, 82%).

Provenance & Evidence