Benzene, 1,4-dichloro-2-fluoro- → HCID 22489938, compound

HRID 2179956Notes

Reaction equation

HRID 2179956 reaction equation
[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[NH2:7][CH2:8][CH2:9][CH:10]([C:21]1[O:22][CH:23]=[CH:24][N:25]=1)[O:11][C:12]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:13]=1C#N.[Cl:26]C1C=CC(Cl)=CC=1F>>[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[Cl:26][C:13]1[CH:16]=[CH:17][C:18]([Cl:20])=[CH:19][C:12]=1[O:11][CH:10]([C:21]1[O:22][CH:23]=[CH:24][N:25]=1)[CH2:9][CH2:8][NH2:7]

Participants

3

Reactant 2

HCID 136173Benzene, 1,4-dichloro-2-fluoro-HCID 22489966HCID 22489966, compound

Product 1

HCID 22489938HCID 22489938, compound

Procedure

The title compound was prepared from the product from Example 56 (b) and 1,4-dichloro-2-fluoro-benzene using similar procedures to Example 56 (c). Final purification was by recrystallisation (2-propanol/methanol/diethyl ether) to afford a beige solid.

Workup

  1. customFinal purification
  2. customwas by recrystallisation (2-propanol/methanol/diethyl ether)
  3. customto afford a beige solid

Sources & evidence

ORD record
ord-e5dcd1f0a1fa4e7c9641833c3c5c970d
Source dataset
uspto-grants-2005_05
Patent number
US06887871B2

Reaction notes

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