4-Chloro-2-hydroxybenzonitrile → 4-Chloro-2-[3-chloro-1-(5-isoxazolyl)propoxy]-benzonitrile

HRID 2179964Notes

Reaction equation

HRID 2179964 reaction equation
[Cl:1][CH2:2][CH2:3][CH:4]([C:6]1[O:10][N:9]=[CH:8][CH:7]=1)[OH:5].[Cl:11][C:12]1[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[C:14](O)[CH:13]=1>>[Cl:11][C:12]1[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[C:14]([O:5][CH:4]([C:6]2[O:10][N:9]=[CH:8][CH:7]=2)[CH2:3][CH2:2][Cl:1])[CH:13]=1

Participants

3

Reactant 2

HCID 34427894-Chloro-2-hydroxybenzonitrileHCID 22489079alpha-(2-Chloroethyl)-5-isoxazolemethanol

Product 1

HCID 224890374-Chloro-2-[3-chloro-1-(5-isoxazolyl)propoxy]-benzonitrile

Procedure

Prepared by the method of Example 8(a) using α-(2-chloroethyl)-5-isoxazolemethanol and 4-chloro-2-hydroxybenzonitrile.

Workup

  1. customPrepared by the method of Example 8(a)

Sources & evidence

ORD record
ord-436faca3d6424c3782605d20b26124b8
Source dataset
uspto-grants-2005_05
Patent number
US06887871B2

Reaction notes

Loading…