HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-hydroxybenzonitrile → 4-Chloro-2-[[(1R)-3-chloro-1-(2-thienyl)propyl]oxy]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-hydroxybenzonitrile | HCID 3442789 | — |
| Reactant | (S)-3-Chloro-1-(thiophen-2-yl)propan-1-ol | HCID 10236042 | — |
| Product | 4-Chloro-2-[[(1R)-3-chloro-1-(2-thienyl)propyl]oxy]benzonitrile | HCID 69802591 | — |
Reaction Steps
Using 4-chloro-2-hydroxybenzonitrile (303 mg, 1.97 mmol) and (S)-α-(2-chloroethyl) thiophenemethanol (349 mg, 1.97 mmol), and the procedure described in Example 5(a), the title compound was prepared as a white crystalline solid (373 mg, 61%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06887871B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-602e5c1fe0f8430c8b73d02b19cfdb57 |
| Source note | uspto-grants-2005_05 |