4-Chloro-2,5-difluorobenzonitrile → HCID 69801673, compound

HRID 2179974Notes

Reaction equation

HRID 2179974 reaction equation
[Cl:1][CH2:2][CH2:3][C@H:4]([C:6]1[CH:10]=[CH:9][S:8][CH:7]=1)[OH:5].[Cl:11][C:12]1[C:19]([F:20])=[CH:18][C:15]([C:16]#[N:17])=[C:14](F)[CH:13]=1>>[Cl:11][C:12]1[C:19]([F:20])=[CH:18][C:15]([C:16]#[N:17])=[C:14]([O:5][C@@H:4]([C:6]2[CH:10]=[CH:9][S:8][CH:7]=2)[CH2:3][CH2:2][Cl:1])[CH:13]=1

Participants

3

Reactant 2

HCID 112753024-Chloro-2,5-difluorobenzonitrileHCID 69648292HCID 69648292, compound

Product 1

HCID 69801673HCID 69801673, compound

Procedure

Using the product of step (d) (322 mg, 1.84 mmol), 4-chloro-2,5-difluorobenzonitrile (320 mg, 1.84 mmol) and the procedure described in Example 72(c), the title compound was prepared (540 mg, 89%).

Sources & evidence

ORD record
ord-2e147d6c23fd4c15833e6ef43d3761a1
Source dataset
uspto-grants-2005_05
Patent number
US06887871B2

Reaction notes

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