(1R)-3-chloro-1-phenylpropan-1-ol → 4-Bromo-2-[[(1R)-3-chloro-1-phenylpropyl]oxy]-5-fluorobenzonitrile

HRID 2179980Notes

Reaction equation

HRID 2179980 reaction equation
[Br:1][C:2]1[C:9]([F:10])=[CH:8][C:5]([C:6]#[N:7])=[C:4](F)[CH:3]=1.[Cl:12][CH2:13][CH2:14][C@H:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[OH:16]>>[Br:1][C:2]1[C:9]([F:10])=[CH:8][C:5]([C:6]#[N:7])=[C:4]([O:16][C@@H:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:14][CH2:13][Cl:12])[CH:3]=1

Participants

3

Reactant 2

HCID 642409(1R)-3-chloro-1-phenylpropan-1-olHCID 149849124-Bromo-2,5-difluorobenzonitrile

Product 1

HCID 697989324-Bromo-2-[[(1R)-3-chloro-1-phenylpropyl]oxy]-5-fluorobenzonitrile

Procedure

This was prepared by the method of Example 43(a) using 4-bromo-2,5-difluorobenzonitrile and (R)-α-(2-chloroethyl)benzenemethanol.

Workup

  1. customThis was prepared by the method of Example 43(a)

Sources & evidence

ORD record
ord-d1a0036c030b4ac980b1c9d0ee1a4416
Source dataset
uspto-grants-2005_05
Patent number
US06887871B2

Reaction notes

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