Tetrahydrofuran → HCID 69800096, compound

Participants

Reaction Steps

The solution produced in step (a) was treated with tetrahydrofuran (10 ml), water (1 ml) and triphenylphosphine (0.3 g) and stirred at ambient temperature for 36 h. The mixture was poured into saturated sodium bicarbonate (20 ml) and extracted into ethyl acetate. The extract was evaporated to dryness and the residue loaded onto an ion exchange resin (SCX isolute) and washed with acetonitrile and methanol. The product was eluted off the column with 7M ammonia in methanol to give an oil which was converted into the fumarate salt (0.104 g).

Provenance & Evidence