Phosphorus oxychloride → HCID 22490054, compound

Participants

Reaction Steps

The product from step 2 (444 mg) is dissolved in POCl3 (1 mL) and DMF (N,N-dimethylformamide, 15 mL), and the resulting solution is stirred at 60° C. for 5 hours. The reaction mixture is cooled, and the volatiles removed under reduced pressure. Flash chromatography (30% ethyl acetate in hexanes) affords 2-chloro-5-(2,4-dimethoxy-phenyl)-3,6-dimethyl-pyrazine as a clear oil. MS: 279.

Provenance & Evidence