HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitrogen → 4-((3-Hydroxypropyl)amino)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitrogen | HCID 947 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 3-Amino-1-propanol | HCID 9086 | — |
| Reactant | 4-Fluorobenzonitrile | HCID 14517 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4-((3-Hydroxypropyl)amino)benzonitrile | HCID 21867663 | 84% |
Reaction Steps
A mixture of 4-fluorobenzonitrile (1.0 g, 8.26 mmol) and 3-aminopropanol (4.54 g, 58.7 mmol) was refluxed under an inert atmosphere (N2) for 15 h. Water (500 mL) and diethyl ether (500 mL) were then added, and the resulting organic layer separated, dried (Na2SO4) and concentrated. The residue was purified by column chromatography (heptane:EtOAc; 1:3) to give the sub-title compound in 84% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06887881B1 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-449aec441f5a4fbaa22005e375bf7cc3 |
| Source note | uspto-grants-2005_05 |