HCID 22490251, compound → HCID 22490283, compound

Participants

Reaction Steps

tert-Butyl 7-[2-{[(benzyloxy)carbonyl]amino}-3-(4-cyanophenoxy)propyl]-9-hydroxy-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate (from step (i) above; 6.17 g; 11.2 mmol) was dissolved in ethanol (56 mL; 85%) and hydrogenated over Pd/C (5%). The resultant mixture was filtered, the solvent was evaporated and the crude product was purified by chromatography on silica (toluene:ethyl acetate:isopropanol; 8:1:1) which gave 2.99 g (64%) of the tide compound.

Provenance & Evidence