HCID 561073, compound → HCID 17571641, compound

HRID 2180021Notes

Reaction equation

HRID 2180021 reaction equation
[CH2:1]([N:8]1[CH2:15][C:14]2([CH3:18])[CH:16]([OH:17])[C:10]([CH3:26])([CH2:11][N:12](CC3C=CC=CC=3)[CH2:13]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C.[Pd]>[CH2:1]([N:8]1[CH2:9][C:10]2([CH3:26])[CH:16]([OH:17])[C:14]([CH3:18])([CH2:13][NH:12][CH2:11]2)[CH2:15]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 561073HCID 561073, compound

Product 1

HCID 17571641HCID 17571641, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 3,7-dibenzyl-1,5-dimethyl-9-hydroxy-3,7-diazabicyclo-[3.3.1]nonane (from step (i) above; 2.71 g, 7.74 mmol) in aqueous ethanol (20 mL; 95%) was hydrogenated over 5% Pd/C at 1 atm. until tlc indicated that the reaction was complete. The catalyst was removed by filtration through a pad of Celite®, and the filtrate concentrated to give the sub-title compound in a quantitative yield.

Workup

  1. customThe catalyst was removed by filtration through a pad of Celite®
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-9e96137bc0844bdd940e597a5f1f78d9
Source dataset
uspto-grants-2005_05
Patent number
US06887881B1

Reaction notes

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