3-Fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → 1-[4-Fluoro-3-(5-fluoropyridin-3-yl)phenyl]-5-methyl-1,5-dihydroimidazo[4,5-c]pyridin-4-one

Beteiligte Stoffe

Reaktionsschritte

1-(3-Bromo-4-fluorophenyl)-5-methyl-1,5-dihydroimidazo[4,5-c]pyridin-4-one was coupled to 3-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine, in the same way as in Example 1, to give 1-[4-fluoro-3-(5-fluoropyridin-3-yl)phenyl]-5-methyl-1,5-dihydroimidazo[4,5-c]pyridin-4-one as an off-white solid (62 mg, 59%): δH (400 MHz, d6-DMSO) 3.69 (3H, s), 6.36 (1H, s), 7.23 (1H, d, J 7), 7.40-7.56 (3H, m), 7.68-7.69 (1H, m), 7.94 (1H, s), 8.57 (1H, d, J 3), 8.66 (1H, d, J 1); m/z (ES+) 339 [MH+].

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