3-Pyridinylboronic acid → 1-[4-Fluoro-3-(pyridin-3-yl)phenyl]-5-methyl-1,5-dihydro-imidazo[4,5-c]pyridin-4-one

참여 물질

역할	이름	HCID	투입량
반응물	3-Pyridinylboronic acid	HCID 2734378	—
반응물	1-(3-Bromo-4-fluorophenyl)-5-methyl-1,5-dihydroimidazo[4,5-c]pyridin-4-one	HCID 22490293	—
생성물	1-[4-Fluoro-3-(pyridin-3-yl)phenyl]-5-methyl-1,5-dihydro-imidazo[4,5-c]pyridin-4-one	HCID 22490291	32%

반응 단계

1-(3-Bromo-4-fluorophenyl)-5-methyl-1,5-dihydroimidazo[4,5-c]pyridin-4-one was coupled to 3-pyridylboronic acid, in the same way as in Example 1, to give 1-[4-fluoro-3-(pyridin-3-yl)phenyl]-5-methyl-1,5-dihydro-imidazo[4,5-c]pyridin-4-one as an off-white solid (50 mg, 32%): δH (400 MHz, CDCl3) 3.69 (3H, s), 6.38 (1H, d, J 7), 7.22 (1H, d, J 7), 7.40-7.49 (3H, m), 7.54 (1H, dd, J 7 and 3), 7.90-7.94 (2H, m), 8.70 (1H, dd, J 5 and 2), 8.84 (1H, s); m/z (ES+) 321 [MH+].

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06887885B2
출처 데이터셋	uspto-grants-2005_05
ORD ID	ord-9c1bcfb0ebdf4f6aaacc8d9fc4a96798
출처 메모	uspto-grants-2005_05