(2,3-Difluorophenyl)boronic acid → 5-Methyl-1-(2,2',3'-trifluorobiphenyl-5-yl)-1,5-dihydroimidazo[4,5-c]pyridin-4-one

Participants

Reaction Steps

1-(3-Bromo-4-fluorophenyl)-5-methyl-1,5-dihydroimidazo[4,5-c]pyridin-4-one was coupled to 2,3-difluorobenzeneboronic acid, in the same way as in Example 1, to give 5-methyl-1-(2,2′,3′-trifluorobiphenyl-5-yl)-1,5-dihydroimidazo[4,5-c]pyridin-4-one as an off-white solid (32 mg, 40%): δH(400 MHz, d6-DMSO) 3.54 (3H, s), 6.61 (1H, d, J 7), 7.35-7.41 (1H, m), 7.48 (1H, dd, J 8 and 7), 7.55-7.67 (3H, m), 7.77-7.81 (2H, m), 8.40 (1H, s); m/z (ES+) 356 [MH+].

Provenance & Evidence