Hydroxyamine hydrochloride → HCID 136388571, compound

Participants

Reaction Steps

1-(4-Acetyl-5-hydroxy-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone (190 mg, 0.605 mmol), hydroxylamine HCl (99 mg, 1.21 mmol) and NaOAc (118 mg, 1.21 mmol) were combined in MeOH (4 mL) and H2O (1 mL) and warmed to 65° C. for 18 hours. The mixture was cooled, diluted with H2O and extracted with EtOAc which was dried (Na2SO4), filtered and concentrated to provide a yellow oil (177 mg, 93%).

Provenance & Evidence