HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Pyrrolidineethanol → 4-(4-Fluoro-2-methylindol-5-yloxy)-6-methoxy-7-(2-(pyrrolidin-1-yl)ethoxy)cinnoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Pyrrolidineethanol | HCID 76288 | — |
| Reactant | 4-(4-Fluoro-2-methylindol-5-yloxy)-7-hydroxy-6-methoxycinnoline | HCID 135749776 | — |
| Product | 4-(4-Fluoro-2-methylindol-5-yloxy)-6-methoxy-7-(2-(pyrrolidin-1-yl)ethoxy)cinnoline | HCID 22490019 | 12% |
Reaction Steps
Using an analogous procedure to that described in Example 15, 4-(4-fluoro-2-methylindol-5-yloxy)-7-hydroxy-6-methoxycinnoline (0.2 g, 0.6 mmol), (prepared as described in Example 4), was reacted with 1-(2-hydroxyethyl)pyrrolidine (0.11 ml, 0.9 mmol) to give 4-(4-fluoro-2-methylindol-5-yloxy)-6-methoxy-7-(2-(pyrrolidin-1-yl)ethoxy)cinnoline (30 mg, 12%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06887874B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-7fd0df57568c45a2bb0401099aafb785 |
| Source note | uspto-grants-2005_05 |