反应详情

A solution of 5-methoxy-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (950 mg, 3.14 mmol) and 40% aqueous sodium hydroxide (106 ml) in methanol (160 ml) was heated at reflux for 30 minutes. After cooling, the mixture was poured onto cooled water and extracted with ethyl acetate. The organic layer was separated, washed with water, brine, dried (MgSO4), filtered and evaporated. The residue was purified by column chromatography eluting with ethyl acetate/petroleum ether (1/1). The fractions containing the expected product were combined and evaporated to give 5-methoxy-2-methyl-1H-pyrrolo[2,3-b]pyridine (462 mg, 91%).

1. temperatureat reflux for 30 minutes
2. temperatureAfter cooling
3. additionthe mixture was poured
4. extractionextracted with ethyl acetate
5. customThe organic layer was separated
6. washwashed with water, brine
7. dry with materialdried (MgSO4)
8. filtrationfiltered
9. customevaporated
10. customThe residue was purified by column chromatography
11. washeluting with ethyl acetate/petroleum ether (1/1)
12. additionThe fractions containing the expected product
13. customevaporated