反应详情

A solution of 3,4-difluorophenyl isocyanate (2 g, 10.55 mmol) in t-BuOH (50 mL) was heated at 80° C. for 16 h. The mixture was concentrated by rotary evaporation to give a white solid which was triturated with toluene and evaporated to dryness. Addition of toluene (20 mL) and concentration under vacuum gave (3,4-difluorophenyl)-carbamic acid-tert-butyl ester as a white solid (2.43 g, 100%).

1. concentrationThe mixture was concentrated by rotary evaporation
2. customto give a white solid which
3. customwas triturated with toluene
4. customevaporated to dryness
5. additionAddition of toluene (20 mL) and concentration under vacuum