Trifluoroacetic acid → HCID 68535370, compound

Participants

Reaction Steps

To a stirred solution of (3,4-difluoro-phenyl)-(2-{[4-(4-iodo-phenyl)-1-methyl-piperidin-4-ylmethyl]-amino}-ethyl)-carbamic acid tert-butyl ester (2.03 g, 3.47 mmol) in CH2Cl2 (25 mL) at 0° C. was added TFA (6 mL, to give a 25% v/v solution). The mixture was stirred and warmed to room temperature for 4 h. The solvent was removed by rotary evaporation and the residue was dissolved in EtOAc (50 mL) and washed with 10% aqueous NaHCO3 (2×50 mL). The organic extracts were dried over sodium sulfate, filtered and concentrated by rotary evaporation to give N-(3,4-difluoro-phenyl)—N′-[4-(4-iodo-phenyl)-1-methyl-piperidin-4-ylmethyl]-ethane-1,2-diamine (1.20 g, 96%) as a white solid.

Provenance & Evidence