Methanesulfonyl chloride → HCID 10089054, compound

Participants

Reaction Steps

Using the general method of Example 232, 1-(4-aminobutyl)-2-methyl-1H-imidazo[4,5-c]quinolin-4-amine (1.00 g, 3.7 mmol) was reacted with methanesulfonyl chloride (0.46 mL, 5.9 mmol) to provide 0.16 g of N-[4-(4-amino-2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamide as an off white solid, m.p. 229.4-230.5° C. Analysis: Calculated for C16H21N5O2S 0.25H2O: % C, 54.60; % H, 6.16; % N, 19.90; Found: % C, 54.80; % H, 6.24; % N, 19.58.

Provenance & Evidence