Methanesulfonyl chloride → HCID 10092697, compound

Participants

Reaction Steps

Using the general method of Example 242, 1-(3-amino-2,2-dimethylpropyl)-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine (0.22 g, 0.672 mmol) was reacted with methanesulfonyl chloride (125 μL) to provide 270 mg of N-{3-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2,2-dimethylpropyl}methanesulfonamide as a cream colored powder, m.p. 204.0-206.0° C. Analysis: Calculated for C19H27N5O3S 0.50H2O: % C, 55.05; % H, 6.81; % N, 16.89; % S, 7.74; Found: % C, 55.10; % H, 6.58; % N, 17.23; % S, 7.51. % H2O calculated: 2.17; found: 2.28 (Karl Fisher).

Provenance & Evidence