反应详情

1 g (2.9 mmol) of 2,4-dichloro-5-(5-difluoromethoxy-1-methyl-1H-pyrazol-3-yl)aniline and 2.4 g (29 mmol) of sodium acetate were initially charged in 100 ml of glacial acetic acid, and 0.93 g (5.6 mmol) of bromine was added dropwise at room temperature. The reaction mixture was stirred overnight and then concentrated, and the residue was taken up in toluene and washed with 50 ml of 5% by weight strength aqueous sodium hydroxide solution until neutral. The organic phase was dried over magnesium sulfate and concentrated. This gave 1.3 g of the aniline IVa.4. The product that was obtained was identical to the compound obtained according to example 1.1.

1. concentrationconcentrated
2. washwashed with 50 ml of 5% by weight strength aqueous sodium hydroxide solution until neutral
3. dry with materialThe organic phase was dried over magnesium sulfate
4. concentrationconcentrated
5. customThe product that was obtained
6. customobtained