反应详情

2-Chloro-3′-chloroacetophenone (945.0 mg, 5.0 mmol), triethylamine (0.73 ml, 5.25 mmol), and formic acid (0.23 ml, 5.25 mmol) were added to an ethyl acetate (5.0 ml) solution containing chloro(pentamethylcyclopentadienyl)rhodium (III) (1R,2R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine (1.35 mg, 0.002 mmol, s/c=5000) which was prepared in the same manner as described in Organic Letters, 1999, vol. 1, pp. 841-843, Supporting Information (see the above-described URL), and the mixture was stirred at room temperature for 2 hours. After completion of the reaction, 1 M hydrochloric acid (5.3 ml) was added, and the reaction product was extracted with ethyl acetate (5 ml) and dried over magnesium sulfate. Evaporation of the solvent yielded a desired compound, (+)-2-chloro-1-(3′-chlorophenyl)ethanol (891.5 mg; yield: 93.4%; optical purity: 93.8% ee).

1. customwas prepared in the same manner
2. additionwas added
3. extractionthe reaction product was extracted with ethyl acetate (5 ml)
4. dry with materialdried over magnesium sulfate
5. customEvaporation of the solvent