3-(3-Hydroxyprop-1-ynyl)-N-phenylbenzenesulfonamide → 3-(3-Oxoprop-1-ynyl)-N-phenylbenzenesulfonamide

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Reaction Steps

3-(3-Hydroxyprop-1-ynyl)-N-phenylbenzenesulfonamide (53a) (0.55 g, 1.9 mmol) was dissolved in a solution of Dess-Martin reagent in methylene chloride (0.157 g/ml) (8.2 ml) and the resultant mixture was stirred at ambient temperature for 30 min. The mixture was partitioned between water (50 ml) and ether (50 ml), and ether solution was washed successively with 5% Na2CO3, water, and dried (Na2SO4). The solvents were removed under reduced pressure to give the title compound (0.47 g, 72%) as an oil. The crude product 54a was used in the further step without an additional purification. 1H NMR (DMSO-d6, HMDSO) δ: 6.96-7.41 (5H, m, C6H5); 7.54-8.07 (4H, m, C6H4); 9.45 (1H, s, CH); 10.41 (1H, s, NH).

Provenance & Evidence